LDN-27219 PRECLINICAL RESEARCH FOR DUMMIES

Just one specially exciting compound is LDN-27219. Although most tTG inhibitors are made to bind on the protein crosslinking active web-site, LDN-27219 alternatively binds for the nucleotide binding pocket of the enzyme though it's in its shut-state conformation, and stabilizes that conformation to forestall crosslinking activity.seventy eight Schn